| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ppha_0643 | Ppha_0644 | Ppha_0643 | Ppha_0644 | Hypothetical protein; KEGG: cph:Cpha266_1326 pentapeptide repeat protein. | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.416 |
| Ppha_0644 | Ppha_0643 | Ppha_0644 | Ppha_0643 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | Hypothetical protein; KEGG: cph:Cpha266_1326 pentapeptide repeat protein. | 0.416 |
| Ppha_0644 | Ppha_1890 | Ppha_0644 | Ppha_1890 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.425 |
| Ppha_0644 | birA | Ppha_0644 | Ppha_2840 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.463 |
| Ppha_0644 | gpsA | Ppha_0644 | Ppha_2815 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: plt:Plut_2057 glycerol-3-phosphate dehydrogenase (NAD(P)+). | 0.672 |
| Ppha_0644 | guaA | Ppha_0644 | Ppha_2644 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.431 |
| Ppha_0644 | nnrD | Ppha_0644 | Ppha_1309 | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.539 |
| Ppha_1890 | Ppha_0644 | Ppha_1890 | Ppha_0644 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.425 |
| Ppha_1890 | birA | Ppha_1890 | Ppha_2840 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.658 |
| Ppha_1890 | guaA | Ppha_1890 | Ppha_2644 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.626 |
| birA | Ppha_0644 | Ppha_2840 | Ppha_0644 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.463 |
| birA | Ppha_1890 | Ppha_2840 | Ppha_1890 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.658 |
| birA | guaA | Ppha_2840 | Ppha_2644 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.534 |
| birA | nnrD | Ppha_2840 | Ppha_1309 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.458 |
| gpsA | Ppha_0644 | Ppha_2815 | Ppha_0644 | Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: plt:Plut_2057 glycerol-3-phosphate dehydrogenase (NAD(P)+). | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.672 |
| guaA | Ppha_0644 | Ppha_2644 | Ppha_0644 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.431 |
| guaA | Ppha_1890 | Ppha_2644 | Ppha_1890 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.626 |
| guaA | birA | Ppha_2644 | Ppha_2840 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.534 |
| nnrD | Ppha_0644 | Ppha_1309 | Ppha_0644 | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | PFAM: isochorismatase hydrolase; KEGG: cph:Cpha266_0525 isochorismatase hydrolase. | 0.539 |
| nnrD | birA | Ppha_1309 | Ppha_2840 | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.458 |