| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ppha_0855 | Ppha_0856 | Ppha_0855 | Ppha_0856 | PFAM: Peptidase M23; KEGG: cch:Cag_1281 membrane-bound metallopeptidase-like. | KEGG: plt:Plut_0563 hypothetical protein. | 0.802 |
| Ppha_0855 | murA | Ppha_0855 | Ppha_0854 | PFAM: Peptidase M23; KEGG: cch:Cag_1281 membrane-bound metallopeptidase-like. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.532 |
| Ppha_0855 | nadE | Ppha_0855 | Ppha_0857 | PFAM: Peptidase M23; KEGG: cch:Cag_1281 membrane-bound metallopeptidase-like. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.788 |
| Ppha_0856 | Ppha_0855 | Ppha_0856 | Ppha_0855 | KEGG: plt:Plut_0563 hypothetical protein. | PFAM: Peptidase M23; KEGG: cch:Cag_1281 membrane-bound metallopeptidase-like. | 0.802 |
| Ppha_0856 | murA | Ppha_0856 | Ppha_0854 | KEGG: plt:Plut_0563 hypothetical protein. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.490 |
| Ppha_0856 | nadE | Ppha_0856 | Ppha_0857 | KEGG: plt:Plut_0563 hypothetical protein. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.793 |
| Ppha_1066 | nadE | Ppha_1066 | Ppha_0857 | PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: pvi:Cvib_1320 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.961 |
| Ppha_1890 | birA | Ppha_1890 | Ppha_2840 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.658 |
| Ppha_1890 | murA | Ppha_1890 | Ppha_0854 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.440 |
| Ppha_1890 | murF | Ppha_1890 | Ppha_2898 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.548 |
| Ppha_1890 | nadD | Ppha_1890 | Ppha_2880 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.668 |
| Ppha_1890 | nadE | Ppha_1890 | Ppha_0857 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.516 |
| Ppha_1890 | nadK | Ppha_1890 | Ppha_2808 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.449 |
| Ppha_2702 | nadD | Ppha_2702 | Ppha_2880 | TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; KEGG: cph:Cpha266_2541 competence/damage-inducible protein CinA; Belongs to the CinA family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.672 |
| Ppha_2702 | nadE | Ppha_2702 | Ppha_0857 | TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein; KEGG: cph:Cpha266_2541 competence/damage-inducible protein CinA; Belongs to the CinA family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.530 |
| birA | Ppha_1890 | Ppha_2840 | Ppha_1890 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.658 |
| birA | nadD | Ppha_2840 | Ppha_2880 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.469 |
| birA | nadE | Ppha_2840 | Ppha_0857 | biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.544 |
| murA | Ppha_0855 | Ppha_0854 | Ppha_0855 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | PFAM: Peptidase M23; KEGG: cch:Cag_1281 membrane-bound metallopeptidase-like. | 0.532 |
| murA | Ppha_0856 | Ppha_0854 | Ppha_0856 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | KEGG: plt:Plut_0563 hypothetical protein. | 0.490 |