node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ppha_0867 | Ppha_1232 | Ppha_0867 | Ppha_1232 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | 0.703 |
Ppha_0867 | Ppha_1809 | Ppha_0867 | Ppha_1809 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | PFAM: heat shock protein DnaJ domain protein; Gas vesicle synthesis GvpLGvpF; KEGG: plt:Plut_0698 hypothetical protein. | 0.521 |
Ppha_0867 | dnaJ | Ppha_0867 | Ppha_1088 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.521 |
Ppha_0867 | dnaK | Ppha_0867 | Ppha_2156 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.703 |
Ppha_0867 | groL | Ppha_0867 | Ppha_0834 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.928 |
Ppha_0867 | grpE | Ppha_0867 | Ppha_1087 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.777 |
Ppha_0867 | hslU | Ppha_0867 | Ppha_1209 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.650 |
Ppha_0867 | hslV | Ppha_0867 | Ppha_1208 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.616 |
Ppha_1232 | Ppha_0867 | Ppha_1232 | Ppha_0867 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 0.703 |
Ppha_1232 | Ppha_1809 | Ppha_1232 | Ppha_1809 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | PFAM: heat shock protein DnaJ domain protein; Gas vesicle synthesis GvpLGvpF; KEGG: plt:Plut_0698 hypothetical protein. | 0.860 |
Ppha_1232 | dnaJ | Ppha_1232 | Ppha_1088 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.929 |
Ppha_1232 | groL | Ppha_1232 | Ppha_0834 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.865 |
Ppha_1232 | groS | Ppha_1232 | Ppha_0833 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.703 |
Ppha_1232 | grpE | Ppha_1232 | Ppha_1087 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.939 |
Ppha_1232 | hrcA | Ppha_1232 | Ppha_1086 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.748 |
Ppha_1232 | hslU | Ppha_1232 | Ppha_1209 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.527 |
Ppha_1232 | hslV | Ppha_1232 | Ppha_1208 | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.460 |
Ppha_1809 | Ppha_0867 | Ppha_1809 | Ppha_0867 | PFAM: heat shock protein DnaJ domain protein; Gas vesicle synthesis GvpLGvpF; KEGG: plt:Plut_0698 hypothetical protein. | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 0.521 |
Ppha_1809 | Ppha_1232 | Ppha_1809 | Ppha_1232 | PFAM: heat shock protein DnaJ domain protein; Gas vesicle synthesis GvpLGvpF; KEGG: plt:Plut_0698 hypothetical protein. | KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family. | 0.860 |
Ppha_1809 | dnaK | Ppha_1809 | Ppha_2156 | PFAM: heat shock protein DnaJ domain protein; Gas vesicle synthesis GvpLGvpF; KEGG: plt:Plut_0698 hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.860 |