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folD protein (Pelodictyon phaeoclathratiforme) - STRING interaction network
"folD" - Bifunctional protein FolD in Pelodictyon phaeoclathratiforme
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (295 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (438 aa)
 
 
  0.988
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (365 aa)
   
 
  0.980
purH
Bifunctional purine biosynthesis protein PurH; KEGG- cph-Cpha266_0657 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- MGS domain protein; AICARFT/IMPCHase bienzyme formylation region (525 aa)
 
  0.976
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (288 aa)
 
 
  0.966
Ppha_1647
KEGG- cch-Cag_1108 5,10-methylenetetrahydrofolate reductase; TIGRFAM- 5,10-methylenetetrahydrofolate reductase; PFAM- methylenetetrahydrofolate reductase (289 aa)
   
 
  0.958
Ppha_1357
PFAM- 5-formyltetrahydrofolate cyclo-ligase; KEGG- cch-Cag_0899 5-formyltetrahydrofolate cyclo-ligase, putative; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family (198 aa)
   
 
  0.956
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (200 aa)
 
 
  0.954
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (319 aa)
 
 
  0.933
Ppha_2383
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant (216 aa)
   
 
  0.906
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (513 aa)
   
   
  0.901
Your Current Organism:
Pelodictyon phaeoclathratiforme
NCBI taxonomy Id: 324925
Other names: P. phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme, Pelodictyon phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme DSM 5477, Pelodictyon phaeoclathratiforme str. BU-1, Pelodictyon phaeoclathratiforme strain BU-1
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