STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ppha_2004PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB; KEGG: cph:Cpha266_0729 thiamine biosynthesis protein ThiH. (366 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.999
Ppha_1021
KEGG: cph:Cpha266_1833 putative PAS/PAC sensor protein; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; Stage II sporulation E family protein; PAS fold domain protein; SMART: PAS domain containing protein; protein phosphatase 2C domain protein.
  
  
 0.932
Ppha_2002
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: cph:Cpha266_0731 thiamine biosynthesis protein ThiS.
  
  
 0.928
Ppha_2005
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: cph:Cpha266_0728 UBA/ThiF-type NAD/FAD binding protein.
 
  
 0.912
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.891
Ppha_1014
KEGG: cph:Cpha266_1826 putative anti-sigma regulatory factor, serine/threonine protein kinase.
   
    0.696
Ppha_1499
PFAM: thiamine monophosphate synthase; KEGG: cph:Cpha266_1531 thiamine monophosphate synthase.
  
  
 0.696
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.696
Ppha_1516
KEGG: plt:Plut_1162 putative anti-sigma regulatory factor (serine/threonine protein kinase).
   
    0.696
Ppha_2006
KEGG: gfo:GFO_1511 conserved hypothetical protein, membrane.
       0.671
Your Current Organism:
Pelodictyon phaeoclathratiforme
NCBI taxonomy Id: 324925
Other names: P. phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme DSM 5477, Pelodictyon phaeoclathratiforme str. BU-1, Pelodictyon phaeoclathratiforme strain BU-1
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