Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Ppha_2617PFAM: UvrB/UvrC protein; AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cph:Cpha266_0334 ATPase AAA-2 domain protein; Belongs to the ClpA/ClpB family. (846 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.849
Ppha_1232
KEGG: cph:Cpha266_2261 DnaK like protein; Belongs to the heat shock protein 70 family.
  
 
 0.774
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.774
Ppha_0045
PFAM: ATP-dependent Clp protease adaptor protein ClpS; KEGG: cph:Cpha266_0046 ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family.
  
 
 0.748
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.715
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
  
 
 0.677
Ppha_0431
PFAM: UvrB/UvrC protein; protein of unknown function DUF151; KEGG: cph:Cpha266_0395 protein of unknown function DUF151.
 
  
 0.674
Ppha_0774
PFAM: heat shock protein Hsp20; KEGG: pvi:Cvib_0315 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.613
Ppha_1812
KEGG: plt:Plut_0695 hypothetical protein; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.613
Ppha_2155
PFAM: heat shock protein Hsp20; KEGG: cch:Cag_1892 heat shock protein, HSP20 family; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.613
Your Current Organism:
Pelodictyon phaeoclathratiforme
NCBI taxonomy Id: 324925
Other names: P. phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme BU-1, Pelodictyon phaeoclathratiforme DSM 5477, Pelodictyon phaeoclathratiforme str. BU-1, Pelodictyon phaeoclathratiforme strain BU-1
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