STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (121 aa)    
Predicted Functional Partners:
Sama_1673
KEGG: son:SO2093 hydrogenase accessory protein HypB.
 
 
 0.990
Sama_1678
KEGG: son:SO2098 hydrogenase large chain; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.973
Sama_1671
KEGG: son:SO2091 hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
  
 0.969
Sama_1672
KEGG: son:SO2092 hydrogenase assembly chaperone hypC/hupF.
 
  
 0.967
Sama_1670
KEGG: son:SO2090 hydrogenase expression/formation protein HypE.
 
  
 0.966
Sama_1674
Hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.957
Sama_1676
KEGG: son:SO2096 hydrogenase expression/formation protein.
 
  
 0.901
Sama_1679
Hydrogen:quinone oxidoreductase; KEGG: son:SO2099 hydrogenase small chain.
 
  
 0.885
Sama_2048
ATP-binding protein, Mrp/Nbp35 family; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.791
Sama_1677
KEGG: son:SO2097 quinone-reactive Ni/Fe hydrogenase, cytochrome b subunit.
 
   
 0.782
Your Current Organism:
Shewanella amazonensis
NCBI taxonomy Id: 326297
Other names: S. amazonensis SB2B, Shewanella amazonensis SB2B, Shewanella amazonensis str. SB2B, Shewanella amazonensis strain SB2B
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