STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
ABB43849.1
ATP-dependent citrate lyase beta subunit.
 
 0.985
ABB43319.1
Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.974
ABB44307.1
Succinate dehydrogenase/fumarate reductase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 0.974
ABB44308.1
Succinate dehydrogenase/fumarate reductase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.965
ABB44330.1
2-oxoglutarate:acceptor oxidoreductase delta subunit.
 
 
 0.963
ABB44333.1
2-oxoglutarate:acceptor oxidoreductase gamma subunit.
 
 
 0.962
ABB44331.1
2-oxoglutarate:acceptor oxidoreductase alpha subunit.
  
 
 0.959
ABB44332.1
2-oxoglutarate:acceptor oxidoreductase beta subunit.
  
 
 0.952
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.908
Your Current Organism:
Sulfurimonas denitrificans
NCBI taxonomy Id: 326298
Other names: S. denitrificans DSM 1251, Sulfurimonas denitrificans DSM 1251, Thiomicrospira denitrificans ATCC 33889
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.