STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnD[Protein-PII] uridylyltransferase (PII uridylyl-transferase) (Uridylyl removing enzyme) (UTase); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regul [...] (800 aa)    
Predicted Functional Partners:
glnB-2
Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family.
 
 
 0.994
glnB
Regulatory protein (P-II) for nitrogen assimilation by glutamine synthetase (ATase); Function of strongly homologous gene; regulator.
 
 
 0.987
amtB
Ammonium transport protein (Amt family); Function of homologous gene experimentally demonstrated in an other organism; transporter.
     
 0.849
gltB
Glutamate synthase, large subunit; Function of strongly homologous gene; enzyme.
     
 0.826
glnA
Glutamine synthetase; Function of strongly homologous gene; enzyme.
 
   
 0.822
glnE
Glutamate-ammonia-ligase adenylyltransferase (Glutamine-synthetase adenylyltransferase) (ATASE); Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. Th [...]
 
   
 0.802
amtB-2
Ammonium transport protein (Amt family); Function of strongly homologous gene; transporter.
     
 0.756
glnII
Glutamine synthetase II (Glutamate--ammonia ligase II) (GSII); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.735
nirB
Nitrite reductase, large subunit, nucleotide-binding; Function of strongly homologous gene; enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
     
 0.693
FRAAL0678
Glutamine synthetase (Glutamate--ammonia ligase); Function of strongly homologous gene; enzyme; Belongs to the glutamine synthetase family.
     
 0.673
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.