STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase (P5CR) (P5C reductase); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (260 aa)    
Predicted Functional Partners:
proB
Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.976
FRAAL4348
Putative proline dehydrogenase (Proline dehydrogenase family protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
   
 0.968
proA
Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.928
putA
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor (P5C dehydrogenase); Function of strongly homologous gene; enzyme; Belongs to the aldehyde dehydrogenase family.
 
 
 0.922
FRAAL5012
Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
    
 0.905
pip
Proline iminopeptidase (PIP) (Prolyl aminopeptidase) (PAP); Function of strongly homologous gene; enzyme; Belongs to the peptidase S33 family.
    
  0.902
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.750
FRAAL2202
Putative enzyme with PLP-binding domain; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
  
 0.748
leuD
3-isopropylmalate isomerase, subunit with LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
     
 0.747
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
     
 0.699
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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