STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hemAGlutamyl-tRNA reductase (GluTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (487 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.999
hemD
uroporphyrin-III C-methyltransferase; Function of strongly homologous gene; enzyme.
 
 
 0.995
hemL
Glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent; Function of strongly homologous gene; enzyme.
 
 0.992
FRAAL6024
Putative glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.992
hemB
5-aminolevulinate dehydratase (porphobilinogen synthase); Function of strongly homologous gene; enzyme; Belongs to the ALAD family.
 
  
 0.979
gltX
Glutamyl-tRNA synthetase (Glutamate--tRNA ligase); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
     
 0.971
corA
Uroporphyrin-III C-methyltransferase; Function of strongly homologous gene; enzyme.
 
 
 0.956
cysG
Uroporphyrin-III C-methyltransferase; Function of strongly homologous gene; enzyme.
 
  
 0.921
hemE
Uroporphyrinogen decarboxylase (partial match); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.895
rex
Redox-sensing transcriptional repressor rex (partial match); Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.823
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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