lepA protein (Frankia alni) - STRING interaction network

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lepA

GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (615 aa)

Predicted Functional Partners:

rpsP

0.957

rpsI

0.953

rpsT

0.953

rplT

0.948

rpsB

0.945

rplM

0.943

rpmA

0.943

rplS

0.943

rpsO

0.939

rpsD

0.934

Your Current Organism:

Frankia alni

NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
lepA	rplM	FRAAL2003	FRAAL1114	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.943
lepA	rplS	FRAAL2003	FRAAL5789	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.943
lepA	rplT	FRAAL2003	FRAAL5214	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	50S ribosomal subunit protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.948
lepA	rpmA	FRAAL2003	FRAAL1926	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	50S ribosomal protein L27; Function of strongly homologous gene; structural protein; Belongs to the bacterial ribosomal protein bL27 family.	0.943
lepA	rpsB	FRAAL2003	FRAAL5780	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal protein S2; Function of strongly homologous gene; structural protein; Belongs to the universal ribosomal protein uS2 family.	0.945
lepA	rpsD	FRAAL2003	FRAAL1109	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.934
lepA	rpsI	FRAAL2003	FRAAL1115	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal subunit protein S9; Function of strongly homologous gene; structural protein; Belongs to the universal ribosomal protein uS9 family.	0.953
lepA	rpsO	FRAAL2003	FRAAL5754	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal subunit protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.	0.939
lepA	rpsP	FRAAL2003	FRAAL5792	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal protein S16; Function of strongly homologous gene; structural protein; Belongs to the bacterial ribosomal protein bS16 family.	0.957
lepA	rpsT	FRAAL2003	FRAAL2001	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	30S ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.953
rplM	lepA	FRAAL1114	FRAAL2003	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	GTP-binding elongation factor; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.	0.943
rplM	rplS	FRAAL1114	FRAAL5789	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.998
rplM	rplT	FRAAL1114	FRAAL5214	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	50S ribosomal subunit protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.999
rplM	rpmA	FRAAL1114	FRAAL1926	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	50S ribosomal protein L27; Function of strongly homologous gene; structural protein; Belongs to the bacterial ribosomal protein bL27 family.	0.999
rplM	rpsB	FRAAL1114	FRAAL5780	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal protein S2; Function of strongly homologous gene; structural protein; Belongs to the universal ribosomal protein uS2 family.	0.998
rplM	rpsD	FRAAL1114	FRAAL1109	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.996
rplM	rpsI	FRAAL1114	FRAAL1115	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal subunit protein S9; Function of strongly homologous gene; structural protein; Belongs to the universal ribosomal protein uS9 family.	0.999
rplM	rpsO	FRAAL1114	FRAAL5754	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal subunit protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.	0.995
rplM	rpsP	FRAAL1114	FRAAL5792	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal protein S16; Function of strongly homologous gene; structural protein; Belongs to the bacterial ribosomal protein bS16 family.	0.989
rplM	rpsT	FRAAL1114	FRAAL2001	50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	30S ribosomal protein S20; Binds directly to 16S ribosomal RNA.	0.992

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