| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FRAAL2972 | dnaJ | FRAAL2972 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.920 |
| FRAAL2972 | grpE | FRAAL2972 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.787 |
| FRAAL2972 | grpE-2 | FRAAL2972 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.797 |
| FRAAL2972 | hrcA | FRAAL2972 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.412 |
| FRAAL3270 | dnaJ | FRAAL3270 | FRAAL2007 | Putative Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.920 |
| FRAAL3270 | grpE | FRAAL3270 | FRAAL2604 | Putative Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.794 |
| FRAAL3270 | grpE-2 | FRAAL3270 | FRAAL6640 | Putative Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.803 |
| FRAAL3270 | hrcA | FRAAL3270 | FRAAL2006 | Putative Chaperone protein dnaK (Heat shock protein 70) (Heat shock 70 kDa protein) (HSP70); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.412 |
| FRAAL4947 | dnaJ | FRAAL4947 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.921 |
| FRAAL4947 | grpE | FRAAL4947 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.807 |
| FRAAL4947 | grpE-2 | FRAAL4947 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.796 |
| FRAAL4947 | hrcA | FRAAL4947 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.412 |
| FRAAL5750 | dnaJ | FRAAL5750 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.923 |
| FRAAL5750 | grpE | FRAAL5750 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.834 |
| FRAAL5750 | grpE-2 | FRAAL5750 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.816 |
| FRAAL5750 | hrcA | FRAAL5750 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.412 |
| FRAAL5893 | dnaJ | FRAAL5893 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.924 |
| FRAAL5893 | grpE | FRAAL5893 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.832 |
| FRAAL5893 | grpE-2 | FRAAL5893 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.832 |
| FRAAL5893 | hrcA | FRAAL5893 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.412 |
