node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRAAL2602 | clpB | FRAAL2602 | FRAAL2601 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.810 |
FRAAL2602 | dnaJ | FRAAL2602 | FRAAL2007 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.443 |
FRAAL2602 | dnaJ-2 | FRAAL2602 | FRAAL2603 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.868 |
FRAAL2602 | dnaJ-3 | FRAAL2602 | FRAAL6641 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.443 |
FRAAL2602 | dnaK | FRAAL2602 | FRAAL2605 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Chaperone Hsp70 in DNA biosynthesis/cell division; Function of strongly homologous gene; molecular chaperone; Belongs to the heat shock protein 70 family. | 0.817 |
FRAAL2602 | grpE | FRAAL2602 | FRAAL2604 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.840 |
FRAAL5750 | clpB | FRAAL5750 | FRAAL2601 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.615 |
FRAAL5750 | dnaJ | FRAAL5750 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.926 |
FRAAL5750 | dnaJ-2 | FRAAL5750 | FRAAL2603 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.919 |
FRAAL5750 | dnaJ-3 | FRAAL5750 | FRAAL6641 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.925 |
FRAAL5750 | grpE | FRAAL5750 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.808 |
FRAAL5750 | hrcA | FRAAL5750 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.594 |
FRAAL5893 | clpB | FRAAL5893 | FRAAL2601 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.615 |
FRAAL5893 | dnaJ | FRAAL5893 | FRAAL2007 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.927 |
FRAAL5893 | dnaJ-2 | FRAAL5893 | FRAAL2603 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.922 |
FRAAL5893 | dnaJ-3 | FRAAL5893 | FRAAL6641 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.927 |
FRAAL5893 | grpE | FRAAL5893 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.806 |
FRAAL5893 | hrcA | FRAAL5893 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.594 |
clpB | FRAAL2602 | FRAAL2601 | FRAAL2602 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.810 |
clpB | FRAAL5750 | FRAAL2601 | FRAAL5750 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein; No homology to any previously reported sequences; Belongs to the heat shock protein 70 family. | 0.615 |