STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FRAAL4663Putative aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (240 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate isomerase, subunit with LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.844
leuB
Beta-Isopropylmalate dehydrogenase; Function of strongly homologous gene; enzyme.
 
 
 0.839
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.821
FRAAL3409
2-oxo-hepta-3-ene-1,7-dioic acid hydratase (OHED hydratase); Function of strongly homologous gene; enzyme.
 
  
 0.816
FRAAL4661
Putative Branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.813
ilvI
Acetolactate synthase III, valine-sensitive, large subunit; Function of strongly homologous gene; enzyme.
 
 
 0.754
ilvD
Dihydroxyacid dehydratase; Function of strongly homologous gene; enzyme; Belongs to the IlvD/Edd family.
 
  
 0.754
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.706
FRAAL1802
Putative pyruvate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the TPP enzyme family.
  
 
 0.694
FRAAL3253
Pyruvate-flavodoxin oxidoreductase; Function of strongly homologous gene; enzyme.
  
  
 0.621
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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