STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FRAAL4875Putative N5, N10-methylenetetrahydromethanopterin reductase-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (332 aa)    
Predicted Functional Partners:
FRAAL3106
Hypothetical protein; No homology to any previously reported sequences.
  
  
 
0.929
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.900
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.900
FRAAL3374
Putative Coenzyme F420-dependent N(5), N(10)-methylenetetrahydromethanopterin reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
     0.765
FRAAL5377
Putative monooxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
     0.702
FRAAL1611
Putative FMN-dependnent oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
     0.694
FRAAL0566
Putative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
     0.691
FRAAL1295
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
   
 0.685
FRAAL4422
Putative Coenzyme F420-dependent reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
     0.682
FRAAL2197
Hypothetical protein; No homology to any previously reported sequences.
  
   
 0.678
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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