STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiSThiamine biosynthesis protein ThiS; Function of strongly homologous gene; enzyme. (56 aa)    
Predicted Functional Partners:
thiG
Thiamin biosynthesis enzyme subunit, with ThiH; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.988
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.944
thiC
5'-phosphoryl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-P; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.831
thiD
Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); Function of strongly homologous gene; enzyme.
  
    0.787
moeB
Molybdopterin-synthase sulfurylase; Function of strongly homologous gene; enzyme.
  
 
 0.762
FRAAL0856
Hypothetical protein; No homology to any previously reported sequences.
  
 
 0.708
FRAAL4991
Hypothetical protein; No homology to any previously reported sequences.
  
 
 0.708
FRAAL6033
Putative molybdopterin biosynthesis MoeB protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.708
hesA2
Protein hesA; Function of strongly homologous gene; enzyme.
  
 
 0.708
FRAAL6801
Putative Molybdenum cofactor biosynthesis protein hesA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.708
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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