STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobUBifunctional cobalamin biosynthesis protein cobU [Includes: Cobinamide kinase; Function of strongly homologous gene; enzyme. (483 aa)    
Predicted Functional Partners:
cobD
Cobalamin biosynthesis protein cobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
 
 0.995
cobT
Nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
 0.995
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Function of strongly homologous gene; enzyme.
 
  
 0.992
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.992
bioD
Dethiobiotin synthetase (Cobyric acid synthase); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.961
FRAAL5927
Putative Adenosylcobalamin-dependent diol dehydratase gamma subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the Cob(I)alamin adenosyltransferase family.
    
 0.931
cobB
Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.914
cobL
Precorrin-6Y C5,15-methyltransferase (decarboxylating); Function of strongly homologous gene; enzyme.
 
  
 0.906
cobM
Precorrin-4 C11-methyltransferase (Precorrin-3 methylase); Function of strongly homologous gene; enzyme; Belongs to the precorrin methyltransferase family.
 
  
 0.888
cobI
Cobalamin biosynthesis protein COBIJ; Function of strongly homologous gene; enzyme.
 
  
 0.866
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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