STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribARiboflavin biosynthesis protein ribA [Includes: GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (516 aa)    
Predicted Functional Partners:
ribE
Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.999
ribC
Riboflavin synthase alpha chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.999
FRAAL5222
Putative riboflavin/cytosine deaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 0.996
FRAAL1884
Putative riboflavin/cytosine deaminase (partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 
 0.980
FRAAL2747
Putative GTP cyclohydrolase I (Mycobacteriophage protein Gp6); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
  
 
 0.952
folE2
GTP cyclohydrolase I; Function of strongly homologous gene; enzyme.
  
 
 0.952
ribD
5-amino-6-(5-phosphoribosylamino)uracil reductase (Riboflavin biosynthesis protein ribD); Function of strongly homologous gene; enzyme.
 
 
 0.930
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.907
guaA
GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
  
  
 0.902
FRAAL5224
Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
   
 
 0.901
Your Current Organism:
Frankia alni
NCBI taxonomy Id: 326424
Other names: F. alni ACN14a, Frankia alni ACN14a, Frankia alni str. ACN14a, Frankia alni strain ACN14a, Frankia sp. ACN14a
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