node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRAAL0721 | FRAAL6642 | FRAAL0721 | FRAAL6642 | Hypothetical protein; No homology to any previously reported sequences. | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | 0.491 |
FRAAL0721 | clpB-2 | FRAAL0721 | FRAAL6643 | Hypothetical protein; No homology to any previously reported sequences. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.498 |
FRAAL0721 | dnaK-2 | FRAAL0721 | FRAAL6639 | Hypothetical protein; No homology to any previously reported sequences. | Chaperone Hsp70 in DNA biosynthesis/cell division; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.874 |
FRAAL0721 | grpE | FRAAL0721 | FRAAL2604 | Hypothetical protein; No homology to any previously reported sequences. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.606 |
FRAAL0721 | grpE-2 | FRAAL0721 | FRAAL6640 | Hypothetical protein; No homology to any previously reported sequences. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.606 |
FRAAL0721 | hrcA | FRAAL0721 | FRAAL2006 | Hypothetical protein; No homology to any previously reported sequences. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.634 |
FRAAL4584 | FRAAL6642 | FRAAL4584 | FRAAL6642 | Putative preprotein translocase SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | 0.585 |
FRAAL6642 | FRAAL0721 | FRAAL6642 | FRAAL0721 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Hypothetical protein; No homology to any previously reported sequences. | 0.491 |
FRAAL6642 | FRAAL4584 | FRAAL6642 | FRAAL4584 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Putative preprotein translocase SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.585 |
FRAAL6642 | clpB-2 | FRAAL6642 | FRAAL6643 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.576 |
FRAAL6642 | dnaJ | FRAAL6642 | FRAAL2007 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.630 |
FRAAL6642 | dnaJ-2 | FRAAL6642 | FRAAL2603 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Curved DNA-binding protein, co-chaperone of DnaK (Hsp40 family); Function of strongly homologous gene; molecular chaperone. | 0.630 |
FRAAL6642 | dnaJ-3 | FRAAL6642 | FRAAL6641 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.880 |
FRAAL6642 | dnaK-2 | FRAAL6642 | FRAAL6639 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Chaperone Hsp70 in DNA biosynthesis/cell division; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.642 |
FRAAL6642 | grpE | FRAAL6642 | FRAAL2604 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] | 0.693 |
FRAAL6642 | grpE-2 | FRAAL6642 | FRAAL6640 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Heat shock protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several r [...] | 0.834 |
FRAAL6642 | hrcA | FRAAL6642 | FRAAL2006 | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.568 |
clpB-2 | FRAAL0721 | FRAAL6643 | FRAAL0721 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein; No homology to any previously reported sequences. | 0.498 |
clpB-2 | FRAAL6642 | FRAAL6643 | FRAAL6642 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Putative heat shock protein hspR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | 0.576 |
clpB-2 | dnaJ | FRAAL6643 | FRAAL2007 | ATP-dependent protease, Hsp 100, part of multi-chaperone system with DnaK, DnaJ, and GrpE; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.631 |