Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemDXuroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III C-methyltransferase (C terminal); Function of strongly homologous gene; enzyme. (616 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase (porphobilinogen deaminase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.999
cysG
Multifunctional siroheme synthase: uroporphyrinogen methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
 
 0.983
hemY
Putative HemY (Uncharacterized enzyme of heme biosynthesis); Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy.
 
  
 0.959
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.949
hemB
5-aminolevulinate dehydratase (porphobilinogen synthase); Function of strongly homologous gene; enzyme; Belongs to the ALAD family.
  
 
 0.910
PSHAa0097
Homologs of previously reported genes of unknown function.
       0.813
PSHAa0101
Putative sensor protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; receptor.
       0.804
cyaY
Putative CyaY, involved in iron scavenging and/or transfer to heme; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
       0.787
PSHAa0096
Putative phospholipase/carboxylesterase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
  
    0.787
bcsC
Cellulose synthase operon protein C; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.774
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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