| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpX | hflK | PSHAa2061 | PSHAa0273 | ATPase, chaperone subunit of serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | 0.420 |
| clpX | hfq | PSHAa2061 | PSHAa0271 | ATPase, chaperone subunit of serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Host factor-I; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.872 |
| clpX | ihfA | PSHAa2061 | PSHAa1902 | ATPase, chaperone subunit of serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Integration host factor (IHF), alpha subunit, DNA-bending protein, DNA replication; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.690 |
| csrA | dksAA | PSHAa0534 | PSHAa0606 | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | RNA polymerase factor controlling rRNA transcription with ppGpp as a modulator; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.665 |
| csrA | hfq | PSHAa0534 | PSHAa0271 | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | Host factor-I; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.852 |
| csrA | ihfA | PSHAa0534 | PSHAa1902 | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | Integration host factor (IHF), alpha subunit, DNA-bending protein, DNA replication; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.816 |
| dksAA | csrA | PSHAa0606 | PSHAa0534 | RNA polymerase factor controlling rRNA transcription with ppGpp as a modulator; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 0.665 |
| dksAA | hfq | PSHAa0606 | PSHAa0271 | RNA polymerase factor controlling rRNA transcription with ppGpp as a modulator; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Host factor-I; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.901 |
| dksAA | ihfA | PSHAa0606 | PSHAa1902 | RNA polymerase factor controlling rRNA transcription with ppGpp as a modulator; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Integration host factor (IHF), alpha subunit, DNA-bending protein, DNA replication; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.583 |
| dksAA | pcnB | PSHAa0606 | PSHAa0604 | RNA polymerase factor controlling rRNA transcription with ppGpp as a modulator; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | poly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.683 |
| hflC | hflK | PSHAa0274 | PSHAa0273 | HflC; HflC and HflK could regulate a protease. | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | 0.999 |
| hflC | hflX | PSHAa0274 | PSHAa0272 | HflC; HflC and HflK could regulate a protease. | HflX, putative GTPase subunit of protease with nucleoside triP hydrolase domain; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.865 |
| hflC | hfq | PSHAa0274 | PSHAa0271 | HflC; HflC and HflK could regulate a protease. | Host factor-I; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.938 |
| hflC | miaA | PSHAa0274 | PSHAa0270 | HflC; HflC and HflK could regulate a protease. | Delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.905 |
| hflK | clpX | PSHAa0273 | PSHAa2061 | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | ATPase, chaperone subunit of serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.420 |
| hflK | hflC | PSHAa0273 | PSHAa0274 | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | HflC; HflC and HflK could regulate a protease. | 0.999 |
| hflK | hflX | PSHAa0273 | PSHAa0272 | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | HflX, putative GTPase subunit of protease with nucleoside triP hydrolase domain; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.926 |
| hflK | hfq | PSHAa0273 | PSHAa0271 | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | Host factor-I; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.935 |
| hflK | miaA | PSHAa0273 | PSHAa0270 | HflK complex with HflC; HflC and HflK could encode or regulate a protease. | Delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.912 |
| hflX | hflC | PSHAa0272 | PSHAa0274 | HflX, putative GTPase subunit of protease with nucleoside triP hydrolase domain; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | HflC; HflC and HflK could regulate a protease. | 0.865 |
