node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSHAa1251 | coaE | PSHAa1251 | PSHAa0379 | Putative orphan protein; No homology to any previously reported sequences; Belongs to the P-Pant transferase superfamily. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.904 |
coaD | coaE | PSHAa2282 | PSHAa0379 | Phosphopantetheine adenylyltransferase (PPAT) (Dephospho-CoA pyrophosphorylase); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.940 |
coaE | PSHAa1251 | PSHAa0379 | PSHAa1251 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Putative orphan protein; No homology to any previously reported sequences; Belongs to the P-Pant transferase superfamily. | 0.904 |
coaE | coaD | PSHAa0379 | PSHAa2282 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Phosphopantetheine adenylyltransferase (PPAT) (Dephospho-CoA pyrophosphorylase); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.940 |
coaE | mazG | PSHAa0379 | PSHAa0740 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | 0.906 |
coaE | mgsA | PSHAa0379 | PSHAa2175 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | 0.909 |
coaE | mutM | PSHAa0379 | PSHAa0447 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Formamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.971 |
coaE | pcp | PSHAa0379 | PSHAa1441 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family. | 0.570 |
coaE | pilC | PSHAa0379 | PSHAa0381 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Type IV pilus biogenesis protein PilC; Function of homologous gene experimentally demonstrated in an other organism; membrane component. | 0.832 |
coaE | pilD | PSHAa0379 | PSHAa0380 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Type 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | 0.932 |
coaE | polA | PSHAa0379 | PSHAa2757 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.698 |
coaE | yacG | PSHAa0379 | PSHAa0377 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Conserved protein of unknown function; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.721 |
mazG | coaE | PSHAa0740 | PSHAa0379 | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.906 |
mgsA | coaE | PSHAa2175 | PSHAa0379 | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.909 |
mutM | coaE | PSHAa0447 | PSHAa0379 | Formamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.971 |
mutM | polA | PSHAa0447 | PSHAa2757 | Formamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Multifunctional DNA polymerase I: 5'->3' exonuclease (N-terminal); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.967 |
pcp | coaE | PSHAa1441 | PSHAa0379 | Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.570 |
pilC | coaE | PSHAa0381 | PSHAa0379 | Type IV pilus biogenesis protein PilC; Function of homologous gene experimentally demonstrated in an other organism; membrane component. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.832 |
pilC | pilD | PSHAa0381 | PSHAa0380 | Type IV pilus biogenesis protein PilC; Function of homologous gene experimentally demonstrated in an other organism; membrane component. | Type 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | 0.975 |
pilC | yacG | PSHAa0381 | PSHAa0377 | Type IV pilus biogenesis protein PilC; Function of homologous gene experimentally demonstrated in an other organism; membrane component. | Conserved protein of unknown function; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.612 |