Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ampDN-acetyl-anhydromuramyl-L-alanine amidase; Function of strongly homologous gene; enzyme. (184 aa)    
Predicted Functional Partners:
PSHAa0389
Putative ampicillin resistance protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component.
  
  
 0.900
ampG
Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter.
 
   
 0.885
nadC
Nicotinate-nucleotide pyrophosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family.
  
  
 0.745
anmK
Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
  
   
 0.620
ampC
Putative beta-lactamase precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
      
 0.576
mpl
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase (Murein peptide ligase); Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.
  
   
 0.573
PSHAa0387
Putative orphan protein; No homology to any previously reported sequences.
       0.559
gyrA
DNA gyrase, subunit A, type II topoisomerase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP- [...]
   
  
 0.539
eptA
Lipid A phosphoethanolamine transferase, associated with polymyxin resistance; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.528
nagZ
Beta-hexosaminidase A (N-acetyl-beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Chitobiase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glycosyl hydrolase 3 family.
     
 0.506
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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