Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pdhRTranscriptional repressor for pyruvate dehydrogenase complex (GntR family); Function of strongly homologous gene; regulator. (249 aa)    
Predicted Functional Partners:
aceE
Pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
  
 0.805
aceF
Pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
  
 0.778
PSHAa0978
Putative L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.
  
 0.723
PSHAa2305
Putative orphan protein; No homology to any previously reported sequences.
  
     0.519
hutC
Histidine utilization repressor (GntR family); Function of homologous gene experimentally demonstrated in an other organism; regulator.
  
  
 0.516
syd
Syd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family.
  
     0.473
alyll
Putative chondroitin AC/alginate lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
 
     0.452
lpd
Dihydrolipoyl dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.451
PSHAa0977
Putative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
 
   
 0.426
PSHAa0975
Homologs of previously reported genes of unknown function.
 
     0.422
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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