| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa0546 | PSHAa0548 | PSHAa0546 | PSHAa0548 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Homologs of previously reported genes of unknown function. | 0.603 |
| PSHAa0546 | PSHAa3000 | PSHAa0546 | PSHAa3000 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.653 |
| PSHAa0546 | btuR | PSHAa0546 | PSHAa2563 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | cob(I)alamin and cobinamide ATP-dependent adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.972 |
| PSHAa0546 | cobQ | PSHAa0546 | PSHAa2564 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.984 |
| PSHAa0546 | cobS | PSHAa0546 | PSHAa2998 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.847 |
| PSHAa0546 | cobT | PSHAa0546 | PSHAa2999 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.851 |
| PSHAa0546 | cobU | PSHAa0546 | PSHAa2997 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Bifunctional adenosylcobalamin biosynthesis protein cobU [Includes: Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.985 |
| PSHAa0546 | cysG | PSHAa0546 | PSHAa0213 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Multifunctional siroheme synthase: uroporphyrinogen methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.775 |
| PSHAa0546 | gltB | PSHAa0546 | PSHAb0127 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | Glutamate synthase, large subunit, GOGAT; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.512 |
| PSHAa0546 | mtnN | PSHAa0546 | PSHAa0547 | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.868 |
| PSHAa0548 | PSHAa0546 | PSHAa0548 | PSHAa0546 | Homologs of previously reported genes of unknown function. | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | 0.603 |
| PSHAa0548 | mtnN | PSHAa0548 | PSHAa0547 | Homologs of previously reported genes of unknown function. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.648 |
| PSHAa3000 | PSHAa0546 | PSHAa3000 | PSHAa0546 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative cobalamin biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy. | 0.653 |
| PSHAa3000 | btuR | PSHAa3000 | PSHAa2563 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | cob(I)alamin and cobinamide ATP-dependent adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.753 |
| PSHAa3000 | cobQ | PSHAa3000 | PSHAa2564 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.932 |
| PSHAa3000 | cobS | PSHAa3000 | PSHAa2998 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.993 |
| PSHAa3000 | cobT | PSHAa3000 | PSHAa2999 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.994 |
| PSHAa3000 | cobU | PSHAa3000 | PSHAa2997 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Bifunctional adenosylcobalamin biosynthesis protein cobU [Includes: Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.949 |
| PSHAa3000 | cysG | PSHAa3000 | PSHAa0213 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Multifunctional siroheme synthase: uroporphyrinogen methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.636 |
| PSHAa3000 | gltB | PSHAa3000 | PSHAb0127 | Putative enzymatic protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Glutamate synthase, large subunit, GOGAT; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.432 |