| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa0561 | pepP | PSHAa0561 | PSHAa0562 | Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family. | Proline aminopeptidase P II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. | 0.862 |
| PSHAa0561 | ubiH | PSHAa0561 | PSHAa0563 | Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family. | 2-octaprenyl-6-methoxyphenol hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.812 |
| PSHAa0561 | visC | PSHAa0561 | PSHAa0564 | Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family. | Putative monooxygenase, FAD/NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.812 |
| PSHAa1216 | hemF | PSHAa1216 | PSHAa0029 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.457 |
| PSHAa1216 | ubiG | PSHAa1216 | PSHAa1420 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Bifunctional: 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.485 |
| PSHAa1216 | ubiH | PSHAa1216 | PSHAa0563 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | 2-octaprenyl-6-methoxyphenol hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.628 |
| PSHAa1216 | visC | PSHAa1216 | PSHAa0564 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Putative monooxygenase, FAD/NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.646 |
| PSHAa2298 | ubiA | PSHAa2298 | PSHAa2310 | Putative aromatic acid decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.960 |
| PSHAa2298 | ubiD | PSHAa2298 | PSHAa0105 | Putative aromatic acid decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 3-octaprenyl-4-hydroxybenzoate carboxylyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.994 |
| PSHAa2298 | visC | PSHAa2298 | PSHAa0564 | Putative aromatic acid decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative monooxygenase, FAD/NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.909 |
| hemF | PSHAa1216 | PSHAa0029 | PSHAa1216 | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.457 |
| hemF | ubiH | PSHAa0029 | PSHAa0563 | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 2-octaprenyl-6-methoxyphenol hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.602 |
| hemF | visC | PSHAa0029 | PSHAa0564 | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative monooxygenase, FAD/NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.673 |
| pepP | PSHAa0561 | PSHAa0562 | PSHAa0561 | Proline aminopeptidase P II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. | Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family. | 0.862 |
| pepP | ubiH | PSHAa0562 | PSHAa0563 | Proline aminopeptidase P II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. | 2-octaprenyl-6-methoxyphenol hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.859 |
| pepP | visC | PSHAa0562 | PSHAa0564 | Proline aminopeptidase P II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase M24B family. | Putative monooxygenase, FAD/NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.859 |
| ubiA | PSHAa2298 | PSHAa2310 | PSHAa2298 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Putative aromatic acid decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.960 |
| ubiA | ubiB | PSHAa2310 | PSHAa2928 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.465 |
| ubiA | ubiD | PSHAa2310 | PSHAa0105 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 3-octaprenyl-4-hydroxybenzoate carboxylyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.973 |
| ubiA | ubiG | PSHAa2310 | PSHAa1420 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Bifunctional: 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.868 |