Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)    
Predicted Functional Partners:
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
PSHAa2279
Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
  
 0.977
folK
2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.965
ilvE
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
    
 0.930
ilvD
Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
     
 0.921
ilvD2
Putative dihydroxyacid dehydratase (ilvD-like); Function of strongly homologous gene; enzyme; Belongs to the IlvD/Edd family.
     
 0.921
pepN
Aminopeptidase N, a cysteinylglycinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
    
 
 0.850
pcnB
poly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.835
PSHAa0600
Putative orphan protein; No homology to any previously reported sequences.
       0.825
birA
Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
  
 0.816
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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