| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1310 | lepA | PSHAa1310 | PSHAa0730 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.951 |
| PSHAa1310 | lepB | PSHAa1310 | PSHAa0731 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | Signal peptidase I (SPase I) (Leader peptidase I); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | 0.927 |
| PSHAa1310 | lspA | PSHAa1310 | PSHAa0919 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | Lipoprotein signal peptidase (SPase II)(Prolipoprotein signal peptidase); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.641 |
| PSHAa1310 | rnc | PSHAa1310 | PSHAa0732 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | RNase III, ds RNA; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.785 |
| PSHAa1310 | secY | PSHAa1310 | PSHAa2810 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.802 |
| PSHAa1310 | yidC | PSHAa1310 | PSHAa3022 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | Preprotein translocase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.703 |
| era | lepA | PSHAa0733 | PSHAa0730 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.833 |
| era | lepB | PSHAa0733 | PSHAa0731 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Signal peptidase I (SPase I) (Leader peptidase I); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | 0.812 |
| era | pdxJ | PSHAa0733 | PSHAa0735 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Pyridoxine 5'-phosphate (PNP) synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.950 |
| era | recO | PSHAa0733 | PSHAa0734 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | DNA repair protein recO (Recombination protein O); Involved in DNA repair and RecF pathway recombination. | 0.963 |
| era | rnc | PSHAa0733 | PSHAa0732 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | RNase III, ds RNA; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.989 |
| era | rseC | PSHAa0733 | PSHAa0729 | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | Putative regulator of sigma E (sigma 24) factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; factor. | 0.673 |
| lepA | PSHAa1310 | PSHAa0730 | PSHAa1310 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | 0.951 |
| lepA | era | PSHAa0730 | PSHAa0733 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. | 0.833 |
| lepA | lepB | PSHAa0730 | PSHAa0731 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Signal peptidase I (SPase I) (Leader peptidase I); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | 0.981 |
| lepA | pdxJ | PSHAa0730 | PSHAa0735 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Pyridoxine 5'-phosphate (PNP) synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.796 |
| lepA | recO | PSHAa0730 | PSHAa0734 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | DNA repair protein recO (Recombination protein O); Involved in DNA repair and RecF pathway recombination. | 0.773 |
| lepA | rnc | PSHAa0730 | PSHAa0732 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | RNase III, ds RNA; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.859 |
| lepA | rseC | PSHAa0730 | PSHAa0729 | GTP-binding membrane protein of unknown function; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Putative regulator of sigma E (sigma 24) factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; factor. | 0.745 |
| lepB | PSHAa1310 | PSHAa0731 | PSHAa1310 | Signal peptidase I (SPase I) (Leader peptidase I); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S26 family. | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | 0.927 |
