node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSHAa0744 | mutH | PSHAa0744 | PSHAa0743 | Putative orphan protein; No homology to any previously reported sequences. | Methyl-directed mismatch repair protein with restriction endonuclease-like domain; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.773 |
PSHAa1021 | PSHAa1336 | PSHAa1021 | PSHAa1336 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Homologs of previously reported genes of unknown function; membrane component. | 0.770 |
PSHAa1021 | dam | PSHAa1021 | PSHAa2712 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.626 |
PSHAa1021 | lptC | PSHAa1021 | PSHAa2548 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Conserved protein of unknown function; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.787 |
PSHAa1021 | metJ | PSHAa1021 | PSHAa2724 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Transcriptional repressor for methionine biosynthesis (MetJ family); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.772 |
PSHAa1021 | mutH | PSHAa1021 | PSHAa0743 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Methyl-directed mismatch repair protein with restriction endonuclease-like domain; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.745 |
PSHAa1021 | rraB-2 | PSHAa1021 | PSHAa2583 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | Conserved protein of unknown function; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.774 |
PSHAa1021 | seqA | PSHAa1021 | PSHAa1635 | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | SeqA protein, recognizes hemimethylated GATC motifs; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.739 |
PSHAa1336 | PSHAa1021 | PSHAa1336 | PSHAa1021 | Homologs of previously reported genes of unknown function; membrane component. | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.770 |
PSHAa1336 | dam | PSHAa1336 | PSHAa2712 | Homologs of previously reported genes of unknown function; membrane component. | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.403 |
PSHAa1336 | lptC | PSHAa1336 | PSHAa2548 | Homologs of previously reported genes of unknown function; membrane component. | Conserved protein of unknown function; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.771 |
PSHAa1336 | metJ | PSHAa1336 | PSHAa2724 | Homologs of previously reported genes of unknown function; membrane component. | Transcriptional repressor for methionine biosynthesis (MetJ family); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.762 |
PSHAa1336 | mutH | PSHAa1336 | PSHAa0743 | Homologs of previously reported genes of unknown function; membrane component. | Methyl-directed mismatch repair protein with restriction endonuclease-like domain; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.714 |
PSHAa1336 | rraB-2 | PSHAa1336 | PSHAa2583 | Homologs of previously reported genes of unknown function; membrane component. | Conserved protein of unknown function; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.774 |
PSHAa1336 | seqA | PSHAa1336 | PSHAa1635 | Homologs of previously reported genes of unknown function; membrane component. | SeqA protein, recognizes hemimethylated GATC motifs; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.680 |
PSHAb0092 | mutH | PSHAb0092 | PSHAa0743 | Putative protein with acetate and butyrate kinase domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Methyl-directed mismatch repair protein with restriction endonuclease-like domain; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.848 |
dam | PSHAa1021 | PSHAa2712 | PSHAa1021 | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Homologs of previously reported genes of unknown function; Belongs to the UPF0250 family. | 0.626 |
dam | PSHAa1336 | PSHAa2712 | PSHAa1336 | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Homologs of previously reported genes of unknown function; membrane component. | 0.403 |
dam | lptC | PSHAa2712 | PSHAa2548 | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Conserved protein of unknown function; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.549 |
dam | metJ | PSHAa2712 | PSHAa2724 | DNA adenine methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Transcriptional repressor for methionine biosynthesis (MetJ family); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.697 |