Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase isozyme III small subunit; Function of strongly homologous gene; enzyme.
  
 
 0.993
ilvG
Acetolactate synthase II, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.980
ilvI
Acetolactate synthase isozyme III large subunit; Function of strongly homologous gene; enzyme.
 
 
 0.979
ilvD
Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
 
 
 0.972
ilvD2
Putative dihydroxyacid dehydratase (ilvD-like); Function of strongly homologous gene; enzyme; Belongs to the IlvD/Edd family.
 
 
 0.970
ilvM
Acetolactate synthase II, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.965
leuC
3-isopropylmalate isomerase, subunit with LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.925
thrC
Threonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.916
leuD
3-isopropylmalate isomerase, subunit with LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.892
ilvE
Putative branched-chain amino acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
  
  
 0.855
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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