| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1216 | hemF | PSHAa1216 | PSHAa0029 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.457 |
| PSHAa1216 | ubiF | PSHAa1216 | PSHAa1047 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.566 |
| PSHAa1216 | ubiG | PSHAa1216 | PSHAa1420 | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Bifunctional: 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.485 |
| corC | miaB | PSHAa1043 | PSHAa1046 | Magnesium and cobalt efflux protein corC; Function of strongly homologous gene; transporter. | Involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.633 |
| corC | ubiF | PSHAa1043 | PSHAa1047 | Magnesium and cobalt efflux protein corC; Function of strongly homologous gene; transporter. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.545 |
| corC | ybeY | PSHAa1043 | PSHAa1044 | Magnesium and cobalt efflux protein corC; Function of strongly homologous gene; transporter. | Conserved protein of unknown function; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.963 |
| corC | ybeZ | PSHAa1043 | PSHAa1045 | Magnesium and cobalt efflux protein corC; Function of strongly homologous gene; transporter. | PhoH-like protein; Function of strongly homologous gene; transporter. | 0.901 |
| hemF | PSHAa1216 | PSHAa0029 | PSHAa1216 | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Conserved protein of unknown function with thioredoxin-like domain; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.457 |
| hemF | ubiF | PSHAa0029 | PSHAa1047 | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.603 |
| miaB | corC | PSHAa1046 | PSHAa1043 | Involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | Magnesium and cobalt efflux protein corC; Function of strongly homologous gene; transporter. | 0.633 |
| miaB | ubiF | PSHAa1046 | PSHAa1047 | Involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.709 |
| miaB | ybeY | PSHAa1046 | PSHAa1044 | Involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | Conserved protein of unknown function; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. | 0.939 |
| miaB | ybeZ | PSHAa1046 | PSHAa1045 | Involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | PhoH-like protein; Function of strongly homologous gene; transporter. | 0.907 |
| ubiA | ubiB | PSHAa2310 | PSHAa2928 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.465 |
| ubiA | ubiE | PSHAa2310 | PSHAa2926 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Bifunctional protein [Includes: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.742 |
| ubiA | ubiF | PSHAa2310 | PSHAa1047 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.732 |
| ubiA | ubiG | PSHAa2310 | PSHAa1420 | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | Bifunctional: 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.868 |
| ubiB | ubiA | PSHAa2928 | PSHAa2310 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.465 |
| ubiB | ubiE | PSHAa2928 | PSHAa2926 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | Bifunctional protein [Includes: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.929 |
| ubiB | ubiF | PSHAa2928 | PSHAa1047 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 2-octoprenyl-3-methyl-6-methoxy-1, 4-benzoquinone hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.622 |