| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1217 | PSHAa1219 | PSHAa1217 | PSHAa1219 | Putative orphan protein; No homology to any previously reported sequences; membrane component. | Putative orphan protein; No homology to any previously reported sequences. | 0.444 |
| PSHAa1217 | recN | PSHAa1217 | PSHAa1218 | Putative orphan protein; No homology to any previously reported sequences; membrane component. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.599 |
| PSHAa1219 | PSHAa1217 | PSHAa1219 | PSHAa1217 | Putative orphan protein; No homology to any previously reported sequences. | Putative orphan protein; No homology to any previously reported sequences; membrane component. | 0.444 |
| PSHAa1219 | grpE | PSHAa1219 | PSHAa1222 | Putative orphan protein; No homology to any previously reported sequences. | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | 0.591 |
| PSHAa1219 | hrcA | PSHAa1219 | PSHAa1221 | Putative orphan protein; No homology to any previously reported sequences. | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.683 |
| PSHAa1219 | nadK | PSHAa1219 | PSHAa1220 | Putative orphan protein; No homology to any previously reported sequences. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.772 |
| PSHAa1219 | recN | PSHAa1219 | PSHAa1218 | Putative orphan protein; No homology to any previously reported sequences. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.639 |
| grpE | PSHAa1219 | PSHAa1222 | PSHAa1219 | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | Putative orphan protein; No homology to any previously reported sequences. | 0.591 |
| grpE | hrcA | PSHAa1222 | PSHAa1221 | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.988 |
| grpE | nadK | PSHAa1222 | PSHAa1220 | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.701 |
| grpE | recN | PSHAa1222 | PSHAa1218 | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.550 |
| hrcA | PSHAa1219 | PSHAa1221 | PSHAa1219 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Putative orphan protein; No homology to any previously reported sequences. | 0.683 |
| hrcA | grpE | PSHAa1221 | PSHAa1222 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | 0.988 |
| hrcA | nadK | PSHAa1221 | PSHAa1220 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.745 |
| hrcA | recN | PSHAa1221 | PSHAa1218 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.674 |
| nadK | PSHAa1219 | PSHAa1220 | PSHAa1219 | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Putative orphan protein; No homology to any previously reported sequences. | 0.772 |
| nadK | grpE | PSHAa1220 | PSHAa1222 | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Hsp 24 DnaK nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...] | 0.701 |
| nadK | hrcA | PSHAa1220 | PSHAa1221 | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.745 |
| nadK | recN | PSHAa1220 | PSHAa1218 | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.913 |
| recN | PSHAa1217 | PSHAa1218 | PSHAa1217 | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | Putative orphan protein; No homology to any previously reported sequences; membrane component. | 0.599 |
