node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSHAa1219 | hrcA | PSHAa1219 | PSHAa1221 | Putative orphan protein; No homology to any previously reported sequences. | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.732 |
PSHAa1219 | nadK | PSHAa1219 | PSHAa1220 | Putative orphan protein; No homology to any previously reported sequences. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.808 |
PSHAa1219 | recN | PSHAa1219 | PSHAa1218 | Putative orphan protein; No homology to any previously reported sequences. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.701 |
PSHAa1926 | PSHAb0168 | PSHAa1926 | PSHAb0168 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.906 |
PSHAa1926 | mazG | PSHAa1926 | PSHAa0740 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | 0.911 |
PSHAa1926 | nadD | PSHAa1926 | PSHAa1028 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | Nicotinic acid mononucleotide adenylyltransferase, NAD(P)-requiring; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.904 |
PSHAa1926 | nadE | PSHAa1926 | PSHAa0075 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.906 |
PSHAa1926 | nadK | PSHAa1926 | PSHAa1220 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.903 |
PSHAa1926 | sthA | PSHAa1926 | PSHAa2898 | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.901 |
PSHAb0168 | PSHAa1926 | PSHAb0168 | PSHAa1926 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | 0.906 |
PSHAb0168 | mazG | PSHAb0168 | PSHAa0740 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | 0.901 |
PSHAb0168 | nadD | PSHAb0168 | PSHAa1028 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Nicotinic acid mononucleotide adenylyltransferase, NAD(P)-requiring; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.929 |
PSHAb0168 | nadE | PSHAb0168 | PSHAa0075 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.926 |
PSHAb0168 | nadK | PSHAb0168 | PSHAa1220 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.924 |
PSHAb0168 | sthA | PSHAb0168 | PSHAa2898 | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Soluble pyridine nucleotide transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.910 |
hrcA | PSHAa1219 | PSHAa1221 | PSHAa1219 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Putative orphan protein; No homology to any previously reported sequences. | 0.732 |
hrcA | nadK | PSHAa1221 | PSHAa1220 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.784 |
hrcA | recN | PSHAa1221 | PSHAa1218 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. | 0.731 |
mazG | PSHAa1926 | PSHAa0740 | PSHAa1926 | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | Putative NTP pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the Nudix hydrolase family. | 0.911 |
mazG | PSHAb0168 | PSHAa0740 | PSHAb0168 | Nucleoside triphosphate pyrophosphohydrolase, non-specific; Function of strongly homologous gene; enzyme. | Putative sirtuin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.901 |