| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | ilvA | PSHAa2376 | PSHAa2768 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
| glyA | serB | PSHAa2376 | PSHAa0661 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.942 |
| glyA | trpA | PSHAa2376 | PSHAa1288 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.925 |
| glyA | trpB | PSHAa2376 | PSHAa1289 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.920 |
| ilvA | glyA | PSHAa2768 | PSHAa2376 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
| ilvA | serB | PSHAa2768 | PSHAa0661 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.909 |
| ilvA | trpA | PSHAa2768 | PSHAa1288 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.915 |
| ilvA | trpB | PSHAa2768 | PSHAa1289 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.942 |
| ilvA | trpCF | PSHAa2768 | PSHAa1290 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional: indole-3-glycerolphosphate synthetase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.701 |
| pabA | pabB | PSHAa0192 | PSHAa1165 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
| pabA | trpA | PSHAa0192 | PSHAa1288 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.946 |
| pabA | trpB | PSHAa0192 | PSHAa1289 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.931 |
| pabA | trpCF | PSHAa0192 | PSHAa1290 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Bifunctional: indole-3-glycerolphosphate synthetase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.999 |
| pabA | trpD | PSHAa0192 | PSHAa1291 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
| pabA | trpE | PSHAa0192 | PSHAa1293 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Anthranilate synthase component I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
| pabA | trpG | PSHAa0192 | PSHAa1292 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Anthranilate synthase component II (Glutamine amido-transferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.826 |
| pabB | pabA | PSHAa1165 | PSHAa0192 | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.999 |
| pabB | trpA | PSHAa1165 | PSHAa1288 | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.929 |
| pabB | trpB | PSHAa1165 | PSHAa1289 | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.956 |
| pabB | trpCF | PSHAa1165 | PSHAa1290 | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Bifunctional: indole-3-glycerolphosphate synthetase (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. | 0.998 |
