STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Function of strongly homologous gene; enzyme. (349 aa)    
Predicted Functional Partners:
metK
Methionine adenosyltransferase 1 (AdoMet synthetase); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.976
PSHAa2222
Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (C terminal); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.972
PSHAa2223
putativeB12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy.
  
 
 0.972
PSHAa1471
Homologs of previously reported genes of unknown function.
  
 0.962
metC
Cystathionine beta-lyase, PLP-dependent (beta-cystathionase); Function of strongly homologous gene; enzyme.
  
 
 0.952
mdeA
Probable Methionine gamma-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.952
metB
Cystathionine gamma-synthase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.952
thrA
Bifunctional aspartokinase/homoserine dehydrogenase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.932
metL
Bifunctional: aspartokinase II (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.932
PSHAb0477
Putative cystathionine gamma-synthase or beta-lyase, PLP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
  
 
 0.932
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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