STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
seqASeqA protein, recognizes hemimethylated GATC motifs; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (197 aa)    
Predicted Functional Partners:
pgm
Phosphoglucomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
    0.910
PSHAa1638
Homologs of previously reported genes of unknown function.
 
    0.909
astE
Putative Succinylglutamate desuccinylase AstE; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
 
     0.847
mutH
Methyl-directed mismatch repair protein with restriction endonuclease-like domain; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family.
  
   
 0.801
fldA
Flavodoxin 1; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.
 
  
 0.797
PSHAa1818
Homologs of previously reported genes of unknown function; Belongs to the UPF0352 family.
  
     0.775
yihI
Conserved protein of unknown function; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.
  
   
 0.775
PSHAa2535
Homologs of previously reported genes of unknown function.
  
     0.766
PSHAa1819
Homologs of previously reported genes of unknown function.
  
     0.759
PSHAa1636
Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
       0.758
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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