Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sucDsuccinyl-CoA synthetase, alpha subunit, NAD(P)-binding; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
sdhB
Succinate dehydrogenase, Fe-S protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 0.996
sucB
Dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.995
sdhA
Succinate dehydrogenase flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 0.993
sucA
2-oxoglutarate dehydrogenase E1 component; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.989
sdhC
Putative succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with sdhD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
  
 
 0.986
sdhD
Putative succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with sdhC; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.976
ygfH
propionyl-CoA:succinate-CoA transferase; Function of strongly homologous gene; enzyme.
   
 0.951
aceF
Pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.932
prpB
2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
   
 0.924
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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