Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hflDHomologs of previously reported genes of unknown function. (200 aa)    
Predicted Functional Partners:
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.991
purB
Adenylosuccinate lyase; Function of strongly homologous gene; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
    0.945
PSHAa1693
Putative enzyme with RmlC-like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme.
 
  
 0.795
rnt
RNase T, degrades tRNA, has exonuclease and ssDNAse activity; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.
  
    0.728
PSHAa1812
Homologs of previously reported genes of unknown function.
  
    0.683
PSHAb0508
Homologs of previously reported genes of unknown function.
  
    0.666
PSHAa1694
Putative Glr3403 protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy.
       0.660
PSHAa0561
Homologs of previously reported genes of unknown function; Belongs to the UPF0149 family.
  
    0.580
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
   
    0.561
rluE
Ribosomal large subunit pseudouridine synthase E (Pseudouridylate synthase) (Uracil hydrolyase); Function of strongly homologous gene; enzyme; Belongs to the pseudouridine synthase RsuA family.
       0.512
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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