node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSHAa1719 | cdsA | PSHAa1719 | PSHAa2031 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Phosphatidate cytidylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDS family. | 0.915 |
PSHAa1719 | glyA | PSHAa1719 | PSHAa2376 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
PSHAa1719 | ilvA | PSHAa1719 | PSHAa2768 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.901 |
PSHAa1719 | pgsA | PSHAa1719 | PSHAa1914 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.918 |
PSHAa1719 | pldA | PSHAa1719 | PSHAa0175 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Putative outer membrane phospholipase A precursor; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | 0.900 |
PSHAa1719 | psd | PSHAa1719 | PSHAa0486 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.934 |
PSHAa1719 | sdaA | PSHAa1719 | PSHAa1163 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | L-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
PSHAa1719 | serB | PSHAa1719 | PSHAa0661 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.905 |
PSHAa1719 | trpA | PSHAa1719 | PSHAa1288 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.901 |
PSHAa1719 | trpB | PSHAa1719 | PSHAa1289 | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.901 |
cdsA | PSHAa1719 | PSHAa2031 | PSHAa1719 | Phosphatidate cytidylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDS family. | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | 0.915 |
cdsA | pgsA | PSHAa2031 | PSHAa1914 | Phosphatidate cytidylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDS family. | CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.949 |
glyA | PSHAa1719 | PSHAa2376 | PSHAa1719 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | 0.927 |
glyA | ilvA | PSHAa2376 | PSHAa2768 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
glyA | sdaA | PSHAa2376 | PSHAa1163 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.958 |
glyA | serB | PSHAa2376 | PSHAa0661 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.935 |
glyA | trpA | PSHAa2376 | PSHAa1288 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, alpha protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.930 |
glyA | trpB | PSHAa2376 | PSHAa1289 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.924 |
ilvA | PSHAa1719 | PSHAa2768 | PSHAa1719 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Phosphatidylserine synthase; Function of strongly homologous gene; enzyme. | 0.901 |
ilvA | glyA | PSHAa2768 | PSHAa2376 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |