Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpD2-methyl citrate dehydratase; Function of strongly homologous gene; enzyme. (495 aa)    
Predicted Functional Partners:
prpC
Methylcitrate synthase (citrate synthase 2); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
 
 0.995
prpB
2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
  
 0.968
PSHAa1772
Homologs of previously reported genes of unknown function.
  
 
 0.963
acnB
Bifunctional protein [Includes: aconitate hydratase 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aconitase/IPM isomerase family.
     
 0.925
acnA
Aconitate hydratase (likely to be used in stationary phase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.922
acnA-2
Aconitate hydratase 1; Function of homologous gene experimentally demonstrated in an other organism; carrier.
  
 
 0.922
gltA
Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family.
  
  
 0.763
fumB
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
    0.673
prpE
Propionyl CoA synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.630
PSHAa1451
Beta subunit of a coenzyme A carboxylases family protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
    0.588
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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