Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpCMethylcitrate synthase (citrate synthase 2); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (374 aa)    
Predicted Functional Partners:
acnA-2
Aconitate hydratase 1; Function of homologous gene experimentally demonstrated in an other organism; carrier.
 
 0.997
prpB
2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
 0.996
prpD
2-methyl citrate dehydratase; Function of strongly homologous gene; enzyme.
 
 0.995
acnA
Aconitate hydratase (likely to be used in stationary phase); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.988
mdh
Malate dehydrogenase, NAD(P)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.988
aceF
Pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.966
dbT
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.966
acnB
Bifunctional protein [Includes: aconitate hydratase 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aconitase/IPM isomerase family.
  
 
 0.964
fumC
Fumarase C (fumarate hydratase Class II); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.958
fumB
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.958
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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