| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1800 | acpP | PSHAa1800 | PSHAa1807 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.800 |
| PSHAa1800 | holB | PSHAa1800 | PSHAa1802 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative DNA polymerase III delta' subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.845 |
| PSHAa1800 | mltG | PSHAa1800 | PSHAa1804 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.952 |
| PSHAa1800 | pabC | PSHAa1800 | PSHAa1805 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 4-amino-4-deoxychorismate lyase; Function of strongly homologous gene; enzyme. | 0.888 |
| PSHAa1800 | pilZ | PSHAa1800 | PSHAa1801 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Type 4 fimbrial biogenesis protein PILZ; Function of strongly homologous gene. | 0.809 |
| PSHAa1800 | tmk | PSHAa1800 | PSHAa1803 | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.875 |
| acpP | PSHAa1800 | PSHAa1807 | PSHAa1800 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Putative metallo-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.800 |
| acpP | birA | PSHAa1807 | PSHAa2913 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.447 |
| acpP | holB | PSHAa1807 | PSHAa1802 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Putative DNA polymerase III delta' subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.595 |
| acpP | mltG | PSHAa1807 | PSHAa1804 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.955 |
| acpP | pabC | PSHAa1807 | PSHAa1805 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 4-amino-4-deoxychorismate lyase; Function of strongly homologous gene; enzyme. | 0.882 |
| acpP | pilZ | PSHAa1807 | PSHAa1801 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Type 4 fimbrial biogenesis protein PILZ; Function of strongly homologous gene. | 0.541 |
| acpP | tmk | PSHAa1807 | PSHAa1803 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.962 |
| birA | acpP | PSHAa2913 | PSHAa1807 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.447 |
| birA | folP | PSHAa2913 | PSHAa0871 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.588 |
| birA | pabC | PSHAa2913 | PSHAa1805 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 4-amino-4-deoxychorismate lyase; Function of strongly homologous gene; enzyme. | 0.763 |
| folP | birA | PSHAa0871 | PSHAa2913 | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.588 |
| folP | pabA | PSHAa0871 | PSHAa0192 | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.617 |
| folP | pabB | PSHAa0871 | PSHAa1165 | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Aminodeoxychorismate synthase subunit I, component of p-aminobenzoate synthase multienzyme complex; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.575 |
| folP | pabC | PSHAa0871 | PSHAa1805 | Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 4-amino-4-deoxychorismate lyase; Function of strongly homologous gene; enzyme. | 0.939 |