Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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tolBRequired for outer membrane integrity, uptake of group A colicins, and translocation of phage DNA; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (452 aa)    
Predicted Functional Partners:
cpoB
Putative periplasmic protein contains a protein prenylyltransferase domain; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.
  
 0.995
tolQ
Tol-Pal system protein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
  
 0.995
pal
Required for outer membrane integrity, uptake of group A colicins, and translocation of phage DNA; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 0.990
PSHAa1872
Putative TolA protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter.
  
   0.974
tolR
Biopolymer transport protein TolR; Function of homologous gene experimentally demonstrated in an other organism; transporter.
 
  
 0.967
ecfK
Putative outer membrane protein assembly factor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
  
 0.859
imp
Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
 
  
 0.825
surA
Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
  
  
 0.781
tolC
Outer membrane protein tolC precursor; Function of homologous gene experimentally demonstrated in an other organism; transporter.
  
 
 
 0.771
PSHAa0183
Putative outer membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component.
 
 
 0.747
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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