| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1965 | gloB | PSHAa1965 | PSHAa1966 | Homologs of previously reported genes of unknown function. | Putative hydroxyacylglutathione hydrolase with metallo-hydrolase/oxidoreductase domain; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | 0.817 |
| PSHAa1965 | mltD-2 | PSHAa1965 | PSHAa1967 | Homologs of previously reported genes of unknown function. | Lytic murein transglycosylase C, membrane-bound; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.764 |
| amiB | guaA | PSHAa0268 | PSHAa0649 | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.724 |
| amiB | mltD | PSHAa0268 | PSHAa0293 | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative membrane-bound lytic murein transglycosylase D [Precursor]; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.557 |
| amiB | mltD-2 | PSHAa0268 | PSHAa1967 | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Lytic murein transglycosylase C, membrane-bound; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.541 |
| amiB | mltG | PSHAa0268 | PSHAa1804 | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.550 |
| amiB | purL | PSHAa0268 | PSHAa2330 | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Phophoribosylformylglycinamidine synthase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.478 |
| ampG | anmK | PSHAa2248 | PSHAb0124 | Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.657 |
| ampG | mltD | PSHAa2248 | PSHAa0293 | Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Putative membrane-bound lytic murein transglycosylase D [Precursor]; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.589 |
| ampG | mltD-2 | PSHAa2248 | PSHAa1967 | Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Lytic murein transglycosylase C, membrane-bound; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.586 |
| ampG | mltG | PSHAa2248 | PSHAa1804 | Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.593 |
| anmK | ampG | PSHAb0124 | PSHAa2248 | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative muropeptide transport protein (mFS family), highly conserved in gamma-proteobacteria; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter. | 0.657 |
| anmK | mltD | PSHAb0124 | PSHAa0293 | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative membrane-bound lytic murein transglycosylase D [Precursor]; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.753 |
| anmK | mltD-2 | PSHAb0124 | PSHAa1967 | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Lytic murein transglycosylase C, membrane-bound; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.740 |
| anmK | mltG | PSHAb0124 | PSHAa1804 | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.797 |
| anmK | rlmN | PSHAb0124 | PSHAb0141 | Putative molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Putative pyruvate formate lyase activating enzyme 2; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. | 0.509 |
| gloB | PSHAa1965 | PSHAa1966 | PSHAa1965 | Putative hydroxyacylglutathione hydrolase with metallo-hydrolase/oxidoreductase domain; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | Homologs of previously reported genes of unknown function. | 0.817 |
| gloB | mltD-2 | PSHAa1966 | PSHAa1967 | Putative hydroxyacylglutathione hydrolase with metallo-hydrolase/oxidoreductase domain; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | Lytic murein transglycosylase C, membrane-bound; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.771 |
| guaA | amiB | PSHAa0649 | PSHAa0268 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | N-acetylmuramoyl-l-alanine amidase II, murein hydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.724 |
| guaA | mltD | PSHAa0649 | PSHAa0293 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Putative membrane-bound lytic murein transglycosylase D [Precursor]; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.603 |