| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa1310 | PSHAa2009 | PSHAa1310 | PSHAa2009 | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | Homologs of previously reported genes of unknown function. | 0.403 |
| PSHAa1662 | PSHAa2009 | PSHAa1662 | PSHAa2009 | Competence protein ComEC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Homologs of previously reported genes of unknown function. | 0.648 |
| PSHAa1662 | birA | PSHAa1662 | PSHAa2913 | Competence protein ComEC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.630 |
| PSHAa2008 | PSHAa2009 | PSHAa2008 | PSHAa2009 | Putative orphan protein; No homology to any previously reported sequences. | Homologs of previously reported genes of unknown function. | 0.750 |
| PSHAa2009 | PSHAa1310 | PSHAa2009 | PSHAa1310 | Homologs of previously reported genes of unknown function. | Putative signal peptidase I family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme; Belongs to the peptidase S26 family. | 0.403 |
| PSHAa2009 | PSHAa1662 | PSHAa2009 | PSHAa1662 | Homologs of previously reported genes of unknown function. | Competence protein ComEC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.648 |
| PSHAa2009 | PSHAa2008 | PSHAa2009 | PSHAa2008 | Homologs of previously reported genes of unknown function. | Putative orphan protein; No homology to any previously reported sequences. | 0.750 |
| PSHAa2009 | birA | PSHAa2009 | PSHAa2913 | Homologs of previously reported genes of unknown function. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.441 |
| PSHAa2009 | fumB | PSHAa2009 | PSHAa1166 | Homologs of previously reported genes of unknown function. | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.434 |
| PSHAa2009 | guaA | PSHAa2009 | PSHAa0649 | Homologs of previously reported genes of unknown function. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.415 |
| birA | PSHAa1662 | PSHAa2913 | PSHAa1662 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Competence protein ComEC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.630 |
| birA | PSHAa2009 | PSHAa2913 | PSHAa2009 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Homologs of previously reported genes of unknown function. | 0.441 |
| birA | guaA | PSHAa2913 | PSHAa0649 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.771 |
| fumB | PSHAa2009 | PSHAa1166 | PSHAa2009 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Homologs of previously reported genes of unknown function. | 0.434 |
| guaA | PSHAa2009 | PSHAa0649 | PSHAa2009 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Homologs of previously reported genes of unknown function. | 0.415 |
| guaA | birA | PSHAa0649 | PSHAa2913 | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.771 |