STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSHAa2222Putative B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (C terminal); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (876 aa)    
Predicted Functional Partners:
PSHAa2223
putativeB12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase (N terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy.
 
 0.999
metE
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Function of strongly homologous gene; enzyme.
  
 
 0.972
metA
Homoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
  
  
 0.970
PSHAa0642
Putative orphan protein; No homology to any previously reported sequences.
  
  
 0.969
metC
Cystathionine beta-lyase, PLP-dependent (beta-cystathionase); Function of strongly homologous gene; enzyme.
  
 
 0.968
mdeA
Probable Methionine gamma-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.968
thrA
Bifunctional aspartokinase/homoserine dehydrogenase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.968
metL
Bifunctional: aspartokinase II (N-terminal); Function of homologous gene experimentally demonstrated in an other organism; enzyme; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.968
metB
Cystathionine gamma-synthase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 
 0.968
gcvT
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.947
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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