STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mrcBMurein polymerase, bifunctional murein transglycosylase and transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (780 aa)    
Predicted Functional Partners:
ftsI
Division-specific transpeptidase, penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
 
 
 0.993
mrdA
Cell elongation-specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
 
 
 0.989
mrcA
Penicillin-binding protein 1A; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
0.948
dacA
D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 5; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S11 family.
  
 
 0.937
PSHAa0522
Homologs of previously reported genes of unknown function.
   
 
 0.929
PSHAa2729
Conserved protein of unknown function, putative cell division protein; Homologs of previously reported genes of unknown function.
 
 
 
 0.914
mrdB
Rod shape-determining membrane protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
 
 
 0.762
ftsW
Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
 
 
 
 0.746
PSHAa2257
Putative Ammonium/methylammonium transporter amtB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; transporter.
       0.671
mltG
Conserved protein of unknown function; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
 
   
 0.666
Your Current Organism:
Pseudoalteromonas haloplanktis
NCBI taxonomy Id: 326442
Other names: P. haloplanktis TAC125, Pseudoalteromonas haloplanktis TAC125, Pseudoalteromonas haloplanktis str. TAC125, Pseudoalteromonas haloplanktis strain TAC125
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