| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSHAa0287 | PSHAa2279 | PSHAa0287 | PSHAa2279 | Putative mandelate racemase/muconate lactonizing enzyme family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.543 |
| PSHAa2244 | PSHAa2279 | PSHAa2244 | PSHAa2279 | Putative 2OG-Fe(II) oxygenase superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.682 |
| PSHAa2278 | PSHAa2279 | PSHAa2278 | PSHAa2279 | Putative membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.868 |
| PSHAa2278 | yajQ | PSHAa2278 | PSHAa2277 | Putative membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | Putative low abundance protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; 12381839; Belongs to the UPF0234 family. | 0.752 |
| PSHAa2279 | PSHAa0287 | PSHAa2279 | PSHAa0287 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative mandelate racemase/muconate lactonizing enzyme family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.543 |
| PSHAa2279 | PSHAa2244 | PSHAa2279 | PSHAa2244 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative 2OG-Fe(II) oxygenase superfamily protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; enzyme. | 0.682 |
| PSHAa2279 | PSHAa2278 | PSHAa2279 | PSHAa2278 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | 0.868 |
| PSHAa2279 | birA | PSHAa2279 | PSHAa2913 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.593 |
| PSHAa2279 | panB | PSHAa2279 | PSHAa0602 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.977 |
| PSHAa2279 | panC | PSHAa2279 | PSHAa0601 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.972 |
| PSHAa2279 | yajQ | PSHAa2279 | PSHAa2277 | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Putative low abundance protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; 12381839; Belongs to the UPF0234 family. | 0.752 |
| birA | PSHAa2279 | PSHAa2913 | PSHAa2279 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.593 |
| birA | panB | PSHAa2913 | PSHAa0602 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.816 |
| birA | panC | PSHAa2913 | PSHAa0601 | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.786 |
| panB | PSHAa2279 | PSHAa0602 | PSHAa2279 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.977 |
| panB | birA | PSHAa0602 | PSHAa2913 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.816 |
| panB | panC | PSHAa0602 | PSHAa0601 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.999 |
| panC | PSHAa2279 | PSHAa0601 | PSHAa2279 | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | Putative 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.972 |
| panC | birA | PSHAa0601 | PSHAa2913 | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | Biotin-[protein] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.786 |
| panC | panB | PSHAa0601 | PSHAa0602 | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.999 |