node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSHAa2313 | glpE | PSHAa2313 | PSHAa2314 | Putative GlpG protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | 0.936 |
PSHAa2313 | kbl | PSHAa2313 | PSHAa2316 | Putative GlpG protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.771 |
PSHAa2313 | tdh | PSHAa2313 | PSHAa2315 | Putative GlpG protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.801 |
bioF | tdh | PSHAa1608 | PSHAa2315 | 8-amino-7-oxononanoate synthase (7-keto-8-aminopelargonic acid synthetase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.681 |
glpE | PSHAa2313 | PSHAa2314 | PSHAa2313 | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | Putative GlpG protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | 0.936 |
glpE | kbl | PSHAa2314 | PSHAa2316 | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.769 |
glpE | sodB | PSHAa2314 | PSHAa1215 | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | Iron superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. | 0.685 |
glpE | tdh | PSHAa2314 | PSHAa2315 | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.807 |
hrcA | porA | PSHAa1221 | PSHAa0249 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Periplasmic protein, disulfide bond formation; Function experimentally demonstrated in the studied organism; enzyme. | 0.493 |
hrcA | tdh | PSHAa1221 | PSHAa2315 | Conserved protein of unknown function; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.525 |
ilvA | ltaE | PSHAa2768 | PSHAb0295 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Low-specificity L-threonine aldolase (Low-specificity L-TA); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.925 |
ilvA | tdh | PSHAa2768 | PSHAa2315 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.916 |
ilvA | thrC | PSHAa2768 | PSHAa2377 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.962 |
kbl | PSHAa2313 | PSHAa2316 | PSHAa2313 | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Putative GlpG protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homolgy; membrane component. | 0.771 |
kbl | glpE | PSHAa2316 | PSHAa2314 | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Thiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. | 0.769 |
kbl | ltaE | PSHAa2316 | PSHAb0295 | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Low-specificity L-threonine aldolase (Low-specificity L-TA); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.911 |
kbl | tdh | PSHAa2316 | PSHAa2315 | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.998 |
ltaE | ilvA | PSHAb0295 | PSHAa2768 | Low-specificity L-threonine aldolase (Low-specificity L-TA); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.925 |
ltaE | kbl | PSHAb0295 | PSHAa2316 | Low-specificity L-threonine aldolase (Low-specificity L-TA); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 2-amino-3-ketobutyrate CoA ligase (AKB ligase, glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.911 |
ltaE | tdh | PSHAb0295 | PSHAa2315 | Low-specificity L-threonine aldolase (Low-specificity L-TA); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.902 |